in

Prion-Like Domains in Spike Protein of SARS-CoV-2 Differ Across Its Variants and Enable Changes in Affinity to ACE2

Prion-Like Domains in Spike Protein of SARS-CoV-2 Differ Across Its Variants and Enable Changes in Affinity to ACE2
Prion-Like Domains in Spike Protein of SARS-CoV-2 Differ Across Its Variants and Enable Changes in Affinity to ACE2

“Prions  are proteins that possess a unique conformational conversion (), with the ability to rapidly shift between multiple conformations due to residue hydrophobicity , and viral prion-like proteins are known as potential regulators of viral infections. However, the prion-like domains (PrD) in the SARS-CoV-2 proteome  have not been analyzed

In this in silico study, using the PLAAC algorithm, we identified the presence of prion-like domains in the SARS-CoV-2 spike protein. Compared with other viruses, a striking difference was observed in the distribution of prion-like domains in the spike protein since SARS-CoV-2 is the only coronavirus with a prion-like domain found in the receptor-binding domain of the S1 region of the spike protein

We found substantial differences in the prion-like domain of the S1 region of the spike protein across emerging variants including Omicron”

What do you think?

Written by colinnew

Leave a Reply

Your email address will not be published. Required fields are marked *

WTO warns of ‘polycrisis’

WTO warns of ‘polycrisis’

Canada to Finally End COVID-19 Vaccine Mandates for Domestic Travel, Outbound Flights

Canada to Finally End COVID-19 Vaccine Mandates for Domestic Travel, Outbound Flights