colinnew
“Prions are proteins that possess a unique conformational conversion (), with the ability to rapidly shift between multiple conformations due to residue hydrophobicity , and viral prion-like proteins are known as potential regulators of viral infections. However, the prion-like domains (PrD) in the SARS-CoV-2 proteome have not been analyzed
In this in silico study, using the PLAAC algorithm, we identified the presence of prion-like domains in the SARS-CoV-2 spike protein. Compared with other viruses, a striking difference was observed in the distribution of prion-like domains in the spike protein since SARS-CoV-2 is the only coronavirus with a prion-like domain found in the receptor-binding domain of the S1 region of the spike protein
We found substantial differences in the prion-like domain of the S1 region of the spike protein across emerging variants including Omicron”
